It's a very exciting time. My latest hard sci-fi book, a medical thriller (73K words) called "the K2 Virus" is going into edit this week. It seems to be my most widely accepted novel so far. Daniel isn't a stereotypical action hero, but he's put in dangerous situations because he feels compelled to help others. I enjoyed writing about him because he has to face his own problems to do so. The publication date is set for May 9. I'm doing
preorders on Amazon and have ten reviews on
Goodreads from the ARCs already. The cover, by The Cover Counts, shows a model of MERS rolling over the Blue House in Seoul, their equivalent of the White House here. That's the story in a nutshell. I thought I would offer a peek at the preface and first chapter for the curious. Keep in mind this is raw and before edits.
pitch:
A new variant of the human coronavirus, K2, sweeps through North Korea. An unsuspecting biochemist delivers a routine batch of flu vaccines to Seoul. When he agrees to play translator for an attractive reporter, he stumbles into a perfect storm of political and biological forces. If he’s going to survive, he’ll need all the principles of Taekwondo he’s been taught since childhood: courtesy, integrity, perseverance, a fast kick, and even faster footwork.
Until this project was hijacked by a virus, it was an
exploration into artificial blood and other medical nanotechnology. Yes, these
things exist. The future is here.
When civets were suspected of
causing the Sudden Acute Respiratory Syndrome (SARS) epidemic in China, thousands
were systematically hunted and exterminated. Recent studies suggest that bats
may have been the real culprit, as with Ebola. Nonetheless, the purge left a
void in the ecosystem. The coronavirus has one imperative—multiply. If one host
is eliminated, the virus must adapt to another. Almost any mammal or bird could
be selected. Middle-East Respiratory Syndrome (MERS), the fifth and deadliest incarnation
of human coronavirus, spread through camels. For the purposes of this story,
I’ve invented a fictional variant of the virus, K2, that can spread through
cattle. Otherwise, the science you’ll read is as real as I could make it. See
the cover for a computer model of what the killer looks like under an electron
microscope.
SARS infected over 8000 people,
killing about a tenth of its hosts. The Roman commanders used this tactic,
known as decimation, to strike terror into deserters. Indeed, SARS terrified
people around the globe by the speed at which it propagated. First it takes
over your immune system, and then you become a virus factory, spreading the
disease to anyone who gets within a meter. For the first two to seven days it
feels like any other flu. After a week, most people get pneumonia. In extreme
cases, the entire system crashes in an ominous event called a cytokine storm—a runaway
feedback loop between the immune regulatory system and your white blood cells. Small
pox, Ebola, the Spanish Flu, and all the big plagues had this end game in
common. The old, young, diabetics, and those with immune problems or liver diseases
seem to be hit the hardest. There is no cure. You just have to ride it out and
stay away from others while you struggle to breathe.
That’s not the scary part. Since the
original leap to our species, the virus has been learning by trial and error. The
next time we face the coronavirus, it will have made improvements.
I describe conditions in North
Korea as closely as I could secondhand. The horrific famines of the 1990s
killed over a million people in the Democratic People’s Republic of Korea
(DPRK). No one knows the full extent because the figures were suppressed. Nor
have I been in a DPRK labor camp. The descriptions are stitched together from
statements from rare survivors and former guards who defected. You can see the
camps for yourself on Google Earth. The similarities to Dachau are eerie.
Only an insane person
would get up before dawn to drive more than an hour to a job he doesn’t want.
Daniel Mann fumbled for his glasses beside the alarm clock. Unfortunately, the
vaccine lab was the only place around that offered long-term care benefits for his
mother. While he was at work and on Saturdays, nurses worked twelve-hour shifts,
leaving him with nights and Sundays. As he brushed his teeth, he reflected that
her accident had crippled his future as well.
The foul mood only lasted till he
saw her sleeping. At forty-eight, the woman was still the unwrinkled saint who
had treated him like a prince. She didn’t deserve this. He owed her ten times
the payback, but the hours were killing him. His only hope was that if the
company struck it big, his stock options might enable him to return to school
some day.
“Rise and shine, Mom.” Then he
wheeled over the stand with her hairbrush, toothbrush, and after-bath splash.
In her native Korean, she said,
“Empty that wastebasket before she gets here.”
He rolled his eyes. “The maid comes
on Wednesday. We pay the nurse. If
she wants it clean earlier than that, she can empty it.”
“Medical professionals are not
janitors.”
But
sons with a master’s degree in biochemistry are? She had wanted him to be a
doctor like his famous uncles and father. Maybe Dad’s son from his second wife wouldn’t
turn out to be such a disappointment. Nonetheless, Daniel took the tiny wicker basket
to the kitchen and dumped the contents into the big garbage bin. He lined the wicker
basket with a fresh plastic shopping bag before washing his hands in the sink.
As he returned to her room, she said,
“Women like a tidy man. There are several nice girls at my church you should
meet.”
Daniel smiled. By “nice,” she meant
South Korean. He turned CNN on for her because she liked to stay current. The
lack of rainfall in Korea was affecting farmers. “Remember our deal. Sunday, I
take you in for church and pick you up after the coffee social. I get to eat
out alone.”
“A wife could cook a better
breakfast for you.”
A knock saved him. He kissed his
mother on the forehead and ran to unlatch the door. “Good morning,” he said in
English.
“How is she?” asked Ms. Hernandez.
On Sundays, his mother mingled in
public, and those nights she was always in a world of hurt. “I gave her a dose for
the pain around two this morning, so she’s happy and chatty.”
The thirty-something nurse gave him
a sad smile. “Which means you’re a little tired today. Do you want to take a
nap before work?”
His eyes flicked toward his room. Tempting. With the round trip from the
Philadelphia suburbs to the Baltimore outskirts, he had only half an hour
wiggle room. “No. Every minute I delay, the traffic gets worse.”
“So you work a little less today.
No one will notice.”
“I can’t cut corners. I sign off on
product safety testing.” He pulled his premade lunch and a can of soda out of
the fridge. Then he checked the digital thermometer by the birdfeeder on the
window and grabbed a light jacket. October had brought a chill to the air. “Relieve
you by six tonight as usual.”
“Watch out for the deer,” his
mother shouted from the other room. She’d recently watched a news story about
Pennsylvania ranking second nationwide in the number of deer strikes.
He waved as he ducked through the
garage door. Maybe a crash wouldn’t be so
awful. A stay in the hospital would be my first vacation in years.
His
smartphone was still hooked up to the hybrid car’s sound system. He tapped “resume”
on his current audiobook mystery and pulled out of the garage on mental autopilot.
****
When Daniel pulled up to the gates at Nano-Encapsulated
Vaccine Research (NEVR), he saw a trio of cars in the parking lot. He
double-checked the time because he was usually the first in. He had arrived two
minutes earlier than normal and didn’t recognize the vehicles. The lean, African-American
guard scanning his badge used the same tired joke he did every day. “Dan the
Mann!”
“Hey, Murphy. Who’s here?”
The guard leaned closer to confide,
“Le Grand Fromage escorted a few backers
in.”
The board had appointed a French
lab manager with extensive experience saving imperiled companies. His security
and austerity measures were unpopular, so the employees seldom missed an opportunity
to poke fun at him. Points were awarded for wearing SeƱor
Frog’s T-shirts from Cancun, displaying Kermit the Frog, or using any cheesy
French terms.
The ultra-secure NEVR campus was
called Neverland by its employees, most of whom acted like teenagers. They held
videogame tournaments in the lunchroom, NERF-dart battles in the cubicles, and
contests to see who could cook the hottest chili.
As Daniel drove up to his usual space
by his office, he noted the tax-exempt plates on two visiting sedans—government
vehicles. NEVR belonged to the class of Washington businesses known as Beltway
Bandits. In order to export superior vaccine products all over the world, they
needed a government grant to ramp up to production levels. Last year’s anthrax
vaccine had been a disappointment due to quality-control issues, so everything
rode on the success of this year’s offerings. With flu season almost upon them,
Daniel had delayed the already tardy product with an extra week of testing.
According to company rules, any employee could delay production for safety
reasons. However, management referred to this practice as “standing in front of
the train.” Now, the investors were demanding early morning meetings.
Despite the chill in the air, he
broke out in a sweat on the way to the side security door. He didn’t want to be
responsible for another plant closure. If that happened, no one in the industry
would hire him. Angry employees would egg his car and call his house at all
hours. Last time, someone had lit a paper bag on his porch. Only after stomping
out the smoking mess did he find it was full of cow feces. He’d thrown away
that pair of slippers.
He ran his badge across the reader
and stepped into the sterile hall. Voices from the cubicle farm caused his
stomach to clench. He turned left abruptly, removed the static straps from his
jacket pocket, and tucked them into his shoes. Lately, he spent far more time
in the computer room than any clean room. If people were waiting to ambush him
in his cube, then they wanted to know the results of his test suite. If so, he needed
to see the printouts first and prepare.
Daniel badged into the small
computer room, and the roar of the climate control system assaulted him. He
liked the isolated chamber because it had its own printer, several large
screens, and superuser access. He had also used the electron-microscope data to
run simulations, which required massive computing resources.
He logged in and noted from the
date stamp that the suite had completed thirty minutes ago. Next, he sent the
report to the laser printer and scanned the summary as it emerged. The
contamination tests all came back clean. Only two abnormalities emerged. The
first had been expected. Steeling himself, he picked up the sheaf of papers and
strode toward his cubicle.
The short, squat lab manager spotted
him from a distance, and Henri LeBeau scurried over to shake his hand. He wore
a simple charcoal suit and green power tie. Daniel couldn’t help staring down at
the flagrant comb-over that covered the man’s bald spot. In an outrageous
French accent, LeBeau said, “Monsieur Mann, I have heard your name often
lately. I hope not in vain, eh?”
Daniel struggled not to burst out
laughing. Is this a test?
Fortunately, his family did poker face well. He shook hands with Colonel Branson.
The colonel’s grip was firm and his
crew cut was solid gray. “Like your haircut, son. You ever serve?”
Daniel shook his head. “No, sir,
but high and tight was the style when I attended grad school at UT Austin.”
“Hook ’em Horns!” replied the
colonel, the way an alum would.
This bonding ritual elicited a
smile from LeBeau. “The colonel has a few questions for someone of your
expertise.” He turned to Branson. “Monsieur Mann is one of our most diligent
workers.”
Daniel adjusted his glasses
nervously. “I’m new to vaccines, but I’ll try.”
Branson frowned, an expression that
traveled clear to his eyebrows. “Then why did they hire you?”
“My specialization was
nanomedicine.”
“You’re shittin’ me. Like Star
Trek?”
Daniel nodded. “Here, we use custom
molecules down to .002 microns, the nano level. That’s the new standard in this
industry.”
“Do the Russians have this
capability?”
“Yes, sir. Perftran is a perfluorocarbon
product. PFCs are a relative of Teflon that can carry oxygen in a similar
fashion to red blood cells. If you watched the movie The Abyss, you saw the deep-sea diver breathe the gel form of PFC
instead of air. Other hemoglobin-based oxygen carriers or HBOCs are made from
human or bovine blood. These last longer in the patient and can be stored at
room temperature.”
“Injecting people with cow blood?
What is this, the damned Island of Dr.
Moreau?”
“The hemoglobin molecules are the
same, but the amount of human blood is limited by donations. A lab near my grad
school had a product that washed out during phase II testing. I was doing my
thesis on solving the problems by wrapping the fake red blood cells in a
biodegradable layer and adding a few enzymes. Unfortunately, the company closed
its doors before I could finish. I tried to simulate the rest of the results,
but the tools didn’t exist yet. I spent the rest of my time improving BioSPICE.”
When the colonel looked blank, LeBeau
showed him a little mercy. “It’s a DARPA program to provide a common platform
to model biological processes at the chemical and cellular level. It’s written
in Java for portability.”
“I’ve heard of Java,” replied the
colonel, grateful for something familiar.
“Mr. Mann was so good at this
modeling that Harvard had accepted him into its PhD program. We hired him
away,” bragged LeBeau. “When he worked for Pharmacyte, he saved them the
expense of phase II by finding their flaw through his computer skills.”
Saved
them a lot of salaries, too. Daniel was a little nervous that the head of
the lab knew so much about his history. “Like NASA, human life is our first
mission priority.”
Branson nodded, pleased by the
sentiment. “How did you transition from blood to vaccines?”
Blood
is an $8 billion industry with the stigma of failed start-ups. On the practical
side, vaccines are a well-established $160 billion cash cow. Daniel
couldn’t afford another failure. “I’ve been interested in germs since age
eleven when I almost died of pneumonia.”
“Why NEVR?”
“The encapsulation technology is
identical to the Pharmacyte lab in Pennsylvania. We use the same fabrication
machines, scanners, and contamination tests. Only here, we apply polysaccharide
or PLGA coatings onto vaccines for improved T cell response.”
The lab manager seemed interested
in this revelation, but Daniel had just lost the sponsor. He struggled to
explain the process the way he might to his grandmother. “You know the basic
principle of vaccines. We introduce a dead or weakened bug to the body, so the
immune system learns how to beat it.” On the back of his printout, he sketched
a picture of a dead bacterium. “That learning process only takes place if our
product gets to a memory component known as a T cell. It’s a little fish in a big
bloodstream.” He added a representation of the immune cell.
The guest grunted his vague
recollection of this topic.
Daniel continued. “If we just throw
in an empty hook, we won’t catch many fish. A lot of the vaccine could degrade
before it reached the desired target. Not very efficient. So we bait the hook
with polysaccharide worms in a ball around the dead germ.” He added squiggles
around the bacterium. “This signals the T cells like a dinner bell.” He drew an
arrow from the T cell to the bait.
He pressed on with his sales pitch.
“With this method, we handle the big five—salmonella, strep, pneumonia, flu, and
meningitis. Those can wipe out someone who’s had their spleen removed.” This
scenario was of one his more complex test cases for any new product. “We can also
enhance vaccines for hep B, anthrax, typhoid, herpes simplex, HPV, and
Newcastle.” He had explicitly avoided the subject under current testing—hantavirus.
Asia experienced over sixty thousand cases a year, but a vaccine had never
before been made in the US.
“AIDS?” asked the colonel.
“I’ve read about exotic HIV experiments
with gold encapsulation.”
“Sounds pricey and years away.”
Daniel nodded. “But polysaccharide
is cheap and reproducible.”
Colonel Branson jerked a thumb at
the report Daniel had drawn on the back of. “What do your fancy models say
about my vaccine?”
He handed over the pages. “We knew
it wouldn’t work on infants under eighteen months. Their immune system hasn’t
developed a response to polysaccharides yet. The more expensive version adds a
protein peptide that stimulates extra histamine responses. That’s like adding a
flashy silver lure to the hook as well. However, you wanted the prototype fast
and cheap for combat-age personnel.”
“What happens to kids who take it?
I mean, one of my women could be pregnant.”
“The mother’s immune system covers
the child for six months. Other infants would process it as waste. I modeled
the breakdown using BioSPICE. In the worst-case scenario, the sugars reach the
large intestine and overfeed the bacteria there.”
“What will that cause?” asked the
colonel.
Straight-faced, Daniel replied,
“The baby’s poop will stink more.”
Branson burst out laughing and
clapped Daniel on the back. “I like you, Harvard. The last lab couldn’t even
document their testing procedure. Henri here was showing me the manuals you’ve
written since you’ve been here. I didn’t know there were six hundred types of
blood. You’ve added test cases for every vaccine lab error in the last twenty
years. The government loves paperwork like that. Demonstrate this vaccine by
injecting one of your staff, and you’ve got a contract.”
“What?”
“I believe in an ancient Roman
practice. The engineer who built a bridge should lie under it as the first
wagon rolls across. Makes people more careful.”
The lab manager wore a huge smile.
The company was saved.
“We can do that as soon as a
technician arrives,” Daniel said.
“I want you to do it. I mean, that’s something they teach people to do in
grocery stores, right?”
“You can inject me,” volunteered LeBeau.
Daniel stammered, “Can-can I talk
to you in private a moment, sir?”
“He wants to take my medical
history,” the Frenchman ad-libbed. He guided Daniel to the break room. “Zees ees
the moment of truth. Don’t drop the ball now.”
“Th-there’s a reason I never became
a doctor. I can’t stand the sight of blood,” Daniel admitted. At age sixteen, he
had watched his friend Paul bleed out after a snowmobile accident involving
barbed wire. “I get dizzy. It’s called a vasovagal response.”
“So much for your career as an ax
murderer, eh? Surely you had to inject someone to get your degree.”
“Several rats and a pig.”
“An old frog is not too different.”
The humor shocked Daniel, so the man continued, leading them back to the
colonel. “I trust you with my life. So much that I am naming you head of
testing for the company. Just smile and stick me with a needle. Yes? I will
procure the resources to speed your testing of the next batch. We can’t keep
the customer waiting like this again. You say Pharmacyte has everything we
need? I will convince the board to acquire them from bankruptcy.”
Excitement overcame Daniel’s
reluctance. “The company will compliment ours perfectly, sir.”
LeBeau waved his hand. “Perhaps,
but it is the production capacity we need now. If we can merge quickly, Neverland
can still make a profit this flu season.”
“Yes, sir.”
Pale and shaking, Daniel shoved a
needle into the big cheese’s shoulder. His boss’s boss managed not to wince.
When the dose was administered, LeBeau
announced, “I’m going to escort the first shipment of the product to the base.
The colonel’s men are waiting to deploy. Feel free to take a long lunch and celebrate
your promotion with your friends. Your new office will be ready for you when
you return.”
Daniel’s head was spinning from both
the stabbing and the generosity, so he didn’t monitor himself. “Yeah, you’ll
want to be in the demilitarized zone in case the famine makes the North Koreans
reckless.”
Branson’s head snapped up as if a
gun had been drawn in the room. “Interesting. Who told you that?”
“It’s not brain surgery, sir.
You’re in a rush to get a unit vaccinated for Korean hemorrhagic fever. I watch
the news. There’s only one place that would be necessary for US troops.”
“In the future, keep your guesses
to yourself.” Frowning, the colonel told LeBeau, “I want full DoD contractor
checks done on all your personnel before the next shipment.”
“Of course, sir.”